InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cited2

Summary

InnateDB Protein

IDBP-134874.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cited2

Protein Name

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

Synonyms

AI835299; ER154-like; Mrg1; Msg2; p35srj;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038405

InnateDB Gene

IDBG-134872 (Cited2)

Protein Structure

UniProt Annotation

Function

Transcriptional coactivator of the p300/CBP-mediated trancription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator- activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left- right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269PubMed:10593900, ECO:0000269PubMed:15475956, ECO:0000269PubMed:15750185, ECO:0000269PubMed:16619037, ECO:0000269PubMed:17537799, ECO:0000269PubMed:19457926, ECO:0000269PubMed:21224256}.

Subcellular Localization

Nucleus. Note=Colocalizes with EP300 in dot- like structures. {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:15051727}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003712	transcription cofactor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0035035	histone acetyltransferase binding
GO:0046332	SMAD binding
GO:0050693	LBD domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001568	blood vessel development
GO:0001570	vasculogenesis
GO:0001666	response to hypoxia
GO:0001701	in utero embryonic development
GO:0001829	trophectodermal cell differentiation
GO:0001841	neural tube formation
GO:0001843	neural tube closure
GO:0001889	liver development
GO:0001892	embryonic placenta development
GO:0001944	vasculature development
GO:0001947	heart looping
GO:0002089	lens morphogenesis in camera-type eye
GO:0002244	hematopoietic progenitor cell differentiation
GO:0002521	leukocyte differentiation
GO:0003151	outflow tract morphogenesis
GO:0003156	regulation of organ formation
GO:0003197	endocardial cushion development
GO:0003281	ventricular septum development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007368	determination of left/right symmetry
GO:0007417	central nervous system development
GO:0007422	peripheral nervous system development
GO:0007507	heart development
GO:0007530	sex determination
GO:0007569	cell aging
GO:0008283	cell proliferation
GO:0008584	male gonad development
GO:0009612	response to mechanical stimulus
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0021602	cranial nerve morphogenesis
GO:0022409	positive regulation of cell-cell adhesion
GO:0030325	adrenal gland development
GO:0030336	negative regulation of cell migration
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030851	granulocyte differentiation
GO:0034405	response to fluid shear stress
GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0035802	adrenal cortex formation
GO:0035914	skeletal muscle cell differentiation
GO:0043066	negative regulation of apoptotic process
GO:0043627	response to estrogen
GO:0045787	positive regulation of cell cycle
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046697	decidualization
GO:0048536	spleen development
GO:0048538	thymus development
GO:0048596	embryonic camera-type eye morphogenesis
GO:0048821	erythrocyte development
GO:0060136	embryonic process involved in female pregnancy
GO:0060349	bone morphogenesis
GO:0060411	cardiac septum morphogenesis
GO:0060412	ventricular septum morphogenesis
GO:0060971	embryonic heart tube left/right pattern formation
GO:0061156	pulmonary artery morphogenesis
GO:0061308	cardiac neural crest cell development involved in heart development
GO:0061371	determination of heart left/right asymmetry
GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070986	left/right axis specification
GO:0071363	cellular response to growth factor stimulus
GO:1900164	nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
GO:2000020	positive regulation of male gonad development
GO:2001141	regulation of RNA biosynthetic process