Version 5.4
Mus musculus Gene: Polr2k
Summary
InnateDB Gene IDBG-134954.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Polr2k
Gene Name polymerase (RNA) II (DNA directed) polypeptide K
Synonyms ABC10-alpha; MafY; Mt1a; RPABC4; RPB10alpha; RPB12; RPB7.0
Species Mus musculus
Ensembl Gene ENSMUSG00000045996
Encoded Proteins
IDBP-134956
polymerase (RNA) II (DNA directed) polypeptide K
IDBP-743822
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147669:
This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:36174010-36177010
Strand Forward strand
Band B3.1
Transcripts
ENSMUST00000057177 ENSMUSP00000051968
ENSMUST00000180159 ENSMUSP00000136975
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001054 RNA polymerase I activity
GO:0001055 RNA polymerase II activity
GO:0001056 RNA polymerase III activity
GO:0003677 DNA binding
GO:0003899 DNA-directed RNA polymerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006383 transcription from RNA polymerase III promoter
Cellular Component
GO:0005634 nucleus
GO:0005665 DNA-directed RNA polymerase II, core complex
GO:0005666 DNA-directed RNA polymerase III complex
GO:0005736 DNA-directed RNA polymerase I complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000147669
View Gene Order
ENSBTAG00000022539
Not yet available
Pathways
NETPATH
REACTOME
REACT_230204
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_213655
Transcription-coupled NER (TC-NER) pathway
REACT_239142
Innate Immune System pathway
REACT_245058
RNA Polymerase I Transcription pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_203462
Formation of the Early Elongation Complex pathway
REACT_249110
mRNA Splicing pathway
REACT_223654
Formation of transcription-coupled NER (TC-NER) repair complex pathway
REACT_233104
RNA Polymerase III Transcription Initiation pathway
REACT_244380
RNA Polymerase II Transcription Initiation pathway
REACT_235610
mRNA Splicing - Minor Pathway pathway
REACT_255334
RNA Polymerase II Promoter Escape pathway
REACT_250309
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_257165
RNA Polymerase I Transcription Termination pathway
REACT_230745
Immune System pathway
REACT_235422
Nucleotide Excision Repair pathway
REACT_226759
Formation of RNA Pol II elongation complex pathway
REACT_232708
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_251592
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_261233
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_233397
DNA Repair pathway
REACT_270446
Transcriptional regulation by small RNAs pathway
REACT_226490
RNA Polymerase II Transcription Elongation pathway
REACT_255009
RNA Polymerase II Pre-transcription Events pathway
REACT_218897
Cytosolic sensors of pathogen-associated DNA pathway
REACT_258231
mRNA Capping pathway
REACT_233572
Gene Expression pathway
REACT_206535
Regulatory RNA pathways pathway
REACT_221403
RNA Polymerase III Transcription Termination pathway
REACT_260226
mRNA Splicing - Major Pathway pathway
REACT_232235
RNA Polymerase I Promoter Escape pathway
REACT_224562
Dual incision reaction in TC-NER pathway
REACT_240511
RNA Polymerase I Promoter Clearance pathway
REACT_259097
RNA Polymerase I Chain Elongation pathway
REACT_233950
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_242255
RNA Polymerase II Transcription pathway
REACT_237241
RNA Polymerase III Transcription pathway
REACT_257596
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_240508
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_235780
RNA Polymerase I Transcription Initiation pathway
REACT_205207
RNA Polymerase III Chain Elongation pathway
KEGG
mmu00240
Pyrimidine metabolism pathway
mmu03020
RNA polymerase pathway
mmu00230
Purine metabolism pathway
mmu05016
Huntington's disease pathway
mmu04623
Cytosolic DNA-sensing pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6344
Tat-mediated HIV elongation arrest and recovery pathway
REACT_6143
Pausing and recovery of Tat-mediated HIV elongation pathway
REACT_6354
Viral Messenger RNA Synthesis pathway
REACT_22339
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_63
RNA Polymerase III Transcription Termination pathway
REACT_756
RNA Polymerase III Chain Elongation pathway
REACT_571
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_1036
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_347
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_1074
RNA Polymerase I Transcription Termination pathway
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_1913
RNA Polymerase I Promoter Escape pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_467
mRNA Splicing - Major Pathway pathway
REACT_1753
mRNA Splicing - Minor Pathway pathway
REACT_125
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_1470
mRNA Capping pathway
REACT_12417
MicroRNA (miRNA) biogenesis pathway
REACT_1655
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_22107
RNA Polymerase II Pre-transcription Events pathway
REACT_1845
Formation of RNA Pol II elongation complex pathway
REACT_846
Formation of the Early Elongation Complex pathway
REACT_833
RNA Polymerase II Transcription Elongation pathway
REACT_2089
RNA Polymerase II Promoter Escape pathway
REACT_1851
RNA Polymerase II Transcription Initiation pathway
REACT_834
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_975
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_22201
Formation of HIV elongation complex in the absence of HIV Tat pathway
REACT_6332
HIV Transcription Initiation pathway
REACT_6244
Pausing and recovery of HIV elongation pathway
REACT_6253
RNA Polymerase II HIV Promoter Escape pathway
REACT_6319
Formation of the HIV-1 Early Elongation Complex pathway
REACT_6346
Formation of HIV-1 elongation complex containing HIV-1 Tat pathway
REACT_6162
Tat-mediated elongation of the HIV-1 transcript pathway
REACT_6261
Abortive elongation of HIV-1 transcript in the absence of Tat pathway
REACT_6237
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_6259
HIV elongation arrest and recovery pathway
REACT_6233
Transcription of the HIV genome pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_1941
Formation of transcription-coupled NER (TC-NER) repair complex pathway
REACT_2222
Dual incision reaction in TC-NER pathway
REACT_1628
Transcription-coupled NER (TC-NER) pathway
REACT_6167
Influenza Infection pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_281
RNA Polymerase III Transcription Initiation pathway
REACT_6802
Innate Immune System pathway
REACT_267668
Transcriptional regulation by small RNAs pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_6274
HIV Transcription Elongation pathway
REACT_1366
RNA Polymerase II Transcription pathway
REACT_6900
Immune System pathway
REACT_6256
HIV Life Cycle pathway
REACT_1371
RNA Polymerase III Transcription pathway
REACT_6185
HIV Infection pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_6145
Influenza Life Cycle pathway
REACT_1735
mRNA Splicing pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_1826
Nucleotide Excision Repair pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_216
DNA Repair pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
REACT_12472
Regulatory RNA pathways pathway
REACT_216178
RNA Polymerase III Transcription pathway
REACT_206651
RNA Polymerase III Transcription Initiation From Type 1 Promoter pathway
REACT_221445
RNA Polymerase I Transcription Termination pathway
REACT_209718
RNA Polymerase II Transcription pathway
REACT_207332
mRNA Capping pathway
REACT_205948
mRNA Splicing - Major Pathway pathway
REACT_206725
mRNA Splicing pathway
REACT_220514
RNA Polymerase III Transcription Initiation From Type 2 Promoter pathway
REACT_227775
Transcription-coupled NER (TC-NER) pathway
REACT_205499
RNA Polymerase II Pre-transcription Events pathway
REACT_220974
Cytosolic sensors of pathogen-associated DNA pathway
REACT_203707
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_202835
RNA Polymerase II Promoter Escape pathway
REACT_217354
RNA Polymerase I Promoter Escape pathway
REACT_207088
RNA Polymerase I Transcription pathway
REACT_226022
Gene Expression pathway
REACT_212448
Nucleotide Excision Repair pathway
REACT_213138
Immune System pathway
REACT_269816
Transcriptional regulation by small RNAs pathway
REACT_225163
RNA Polymerase I Chain Elongation pathway
REACT_226302
Processing of Capped Intron-Containing Pre-mRNA pathway
REACT_216254
Formation of transcription-coupled NER (TC-NER) repair complex pathway
REACT_218933
RNA Polymerase II Transcription Elongation pathway
REACT_204262
DNA Repair pathway
REACT_212144
RNA Polymerase III Transcription Initiation pathway
REACT_219298
Dual incision reaction in TC-NER pathway
REACT_209748
RNA Polymerase III Abortive And Retractive Initiation pathway
REACT_206737
Formation of RNA Pol II elongation complex pathway
REACT_208197
RNA Polymerase I Transcription Initiation pathway
REACT_207660
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening pathway
REACT_217207
mRNA Splicing - Minor Pathway pathway
REACT_220130
RNA Pol II CTD phosphorylation and interaction with CE pathway
REACT_208384
RNA Polymerase II Transcription Initiation And Promoter Clearance pathway
REACT_207656
RNA Polymerase II Transcription Initiation pathway
REACT_210892
Regulatory RNA pathways pathway
REACT_205514
Formation of the Early Elongation Complex pathway
REACT_216714
Innate Immune System pathway
REACT_219488
RNA Polymerase I Promoter Clearance pathway
REACT_203737
RNA Polymerase III Chain Elongation pathway
REACT_221998
RNA Polymerase III Transcription Initiation From Type 3 Promoter pathway
REACT_224876
RNA Polymerase III Transcription Termination pathway
KEGG
hsa00240
Pyrimidine metabolism pathway
hsa00230
Purine metabolism pathway
hsa03020
RNA polymerase pathway
hsa05016
Huntington's disease pathway
hsa04623
Cytosolic DNA-sensing pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q63871
TrEMBL Q545V5
UniProt Splice Variant
Entrez Gene 17749
UniGene
RefSeq NM_023127 XM_006536721 XM_006537451 NM_001039368
OMIM
CCDS CCDS56980 CCDS27426
HPRD
IMGT
MGI ID MGI:102725
MGI Symbol Polr2k
EMBL AK003023 BC028543 CH466570 S63758
GenPept AAB27565 AAH28543 BAB22516 EDL29028
RNA Seq Atlas 100862456 102641086 17749

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca