InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fgfr1op

Summary

InnateDB Gene

IDBG-135351.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fgfr1op

Gene Name

Fgfr1 oncogene partner

Synonyms

4930553O10Rik; FOP

Species

Mus musculus

Ensembl Gene

ENSMUSG00000069135

Encoded Proteins

IDBP-135353

Fgfr1 oncogene partner

IDBP-135355

Fgfr1 oncogene partner

IDBP-542748

Fgfr1 oncogene partner

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000213066:
This gene encodes a largely hydrophilic protein postulated to be a leucine-rich protein family member. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. This gene is thought to play an important role in normal proliferation and differentiation of the erythroid lineage. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2008]
This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn\'s disease, Graves\' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:8165501-8196804

Strand

Forward strand

Band

Transcripts

ENSMUST00000097419	ENSMUSP00000095030
ENSMUST00000024636	ENSMUSP00000024636
ENSMUST00000162586
ENSMUST00000161898	ENSMUSP00000123855

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0030292	protein tyrosine kinase inhibitor activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006469	negative regulation of protein kinase activity
GO:0008284	positive regulation of cell proliferation
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0034453	microtubule anchoring
GO:0061099	negative regulation of protein tyrosine kinase activity