Version 5.4
Mus musculus Gene: Sostdc1
Summary
InnateDB Gene IDBG-135453.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sostdc1
Gene Name sclerostin domain containing 1
Synonyms 0610006G05Rik; ectodin; Sostl; USAG-1; Wise
Species Mus musculus
Ensembl Gene ENSMUSG00000036169
Encoded Proteins
IDBP-135455
sclerostin domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171243:
This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:36314169-36318452
Strand Forward strand
Band A3
Transcripts
ENSMUST00000041407 ENSMUSP00000040230
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007389 pattern specification process
GO:0010454 negative regulation of cell fate commitment
GO:0016055 Wnt signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031069 hair follicle morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0060648 mammary gland bud morphogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000171243
View Gene Order
ENSBTAG00000005377
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
bmppathway
BMP receptor signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.398959 Mm.43375
RefSeq NM_025312
OMIM
CCDS CCDS25887
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca