Version 5.4
Homo sapiens Gene: SOSTDC1
Summary
InnateDB Gene IDBG-8900.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOSTDC1
Gene Name sclerostin domain containing 1
Synonyms ECTODIN; USAG1
Species Homo sapiens
Ensembl Gene ENSG00000171243
Encoded Proteins
IDBP-8902
sclerostin domain containing 1
IDBP-237056
sclerostin domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the sclerostin family and encodes an N-glycosylated, secreted protein with a C-terminal cystine knot-like domain. This protein functions as a bone morphogenetic protein (BMP) antagonist. Specifically, it directly associates with BMPs, prohibiting them from binding their receptors, thereby regulating BMP signaling during cellular proliferation, differentiation, and programmed cell death. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:16461481-16530580
Strand Reverse strand
Band p21.1
Transcripts
ENST00000307068 ENSP00000304930
ENST00000396652 ENSP00000379889
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007389 pattern specification process
GO:0010454 negative regulation of cell fate commitment
GO:0016055 Wnt signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0031069 hair follicle morphogenesis
GO:0042475 odontogenesis of dentin-containing tooth
GO:0060648 mammary gland bud morphogenesis
GO:0090090 negative regulation of canonical Wnt signaling pathway
Cellular Component
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036169
View Gene Order
ENSBTAG00000005377
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
bmppathway
BMP receptor signaling
Cross-References
SwissProt Q6X4U4
TrEMBL
UniProt Splice Variant
Entrez Gene 25928
UniGene Hs.595132 Hs.648106 Hs.739272
RefSeq NM_015464
HUGO HGNC:21748
OMIM 609675
CCDS CCDS5360
HPRD 15417
IMGT
EMBL AB059270 AC005014 AC079155 AF361494 AK093408 AL050024 AY255634 BC008484
GenPept AAH08484 AAL57219 AAQ83296 AAQ96855 BAC20331 BAG52710 CAB43243
RNA Seq Atlas 25928

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca