Version 5.4
Mus musculus Gene: Timp1
Summary
InnateDB Gene IDBG-135707.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Timp1
Gene Name tissue inhibitor of metalloproteinase 1
Synonyms Clgi; EPA; Timp; TIMP-1; TPA-S1
Species Mus musculus
Ensembl Gene ENSMUSG00000001131
Encoded Proteins
IDBP-135709
tissue inhibitor of metalloproteinase 1
IDBP-249841
tissue inhibitor of metalloproteinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome X:20870166-20874735
Strand Forward strand
Band A1.3
Transcripts
ENSMUST00000009530 ENSMUSP00000009530
ENSMUST00000115342 ENSMUSP00000110999
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0002020 protease binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0008191 metalloendopeptidase inhibitor activity
GO:0046872 metal ion binding
Biological Process
GO:0001775 cell activation
GO:0007568 aging
GO:0008284 positive regulation of cell proliferation
GO:0010033 response to organic substance
GO:0010951 negative regulation of endopeptidase activity
GO:0034097 response to cytokine
GO:0042060 wound healing
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0048553 negative regulation of metalloenzyme activity
GO:0051045 negative regulation of membrane protein ectodomain proteolysis
GO:1901164 negative regulation of trophoblast cell migration
GO:2001044 regulation of integrin-mediated signaling pathway
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0005615 extracellular space
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_230203
Platelet degranulation pathway
REACT_224553
Hemostasis pathway
REACT_199000
Activation of Matrix Metalloproteinases pathway
REACT_206066
Extracellular matrix organization pathway
REACT_224879
Platelet activation, signaling and aggregation pathway
REACT_206166
Response to elevated platelet cytosolic Ca2+ pathway
REACT_199052
Degradation of the extracellular matrix pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P12032
TrEMBL
UniProt Splice Variant
Entrez Gene 21857
UniGene
RefSeq NM_001044384 NM_011593
OMIM
CCDS CCDS30046
HPRD
IMGT
MGI ID MGI:98752
MGI Symbol Timp1
EMBL BC008107 BC034260 BC051260 M17243 M28308 M28309 M28310 M28311 M28312 V00755 X04684
GenPept AAA40471 AAB42179 AAH08107 AAH34260 AAH51260 CAA24132 CAA28387
RNA Seq Atlas 21857

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca