InnateDB Protein
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IDBP-135709.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Timp1
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Protein Name
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tissue inhibitor of metalloproteinase 1
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Synonyms
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Clgi; EPA; Timp; TIMP-1; TPA-S1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000009530
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InnateDB Gene
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IDBG-135707 (Timp1)
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Protein Structure
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Function |
Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14 (By similarity). Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. {ECO:0000250, ECO:0000269PubMed:23522389}.
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Subcellular Localization |
Secreted {ECO:0000269PubMed:23522389}.
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Disease Associations |
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Tissue Specificity |
Found in fetal and adult tissues. Highest levels are found in bone. Also found in lung, ovary and uterus.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:98752
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InterPro |
IPR001134
Netrin domain
IPR001820
Proteinase inhibitor I35, tissue inhibitor of metalloproteinase
IPR008993
Tissue inhibitor of metalloproteinases-like, OB-fold
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PFAM |
PF00965
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PRINTS |
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PIRSF |
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SMART |
SM00206
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TIGRFAMs |
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Modification |
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SwissProt |
P12032
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
21857
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UniGene |
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RefSeq |
XP_006527645
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MGI ID |
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MGI Symbol |
Timp1
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OMIM |
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CCDS |
CCDS30046
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HPRD |
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IMGT |
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EMBL |
BC008107
BC034260
BC051260
M17243
M28308
M28309
M28310
M28311
M28312
V00755
X04684
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GenPept |
AAA40471
AAB42179
AAH08107
AAH34260
AAH51260
CAA24132
CAA28387
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