InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Etv1

Summary

InnateDB Gene

IDBG-136023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Etv1

Gene Name

ets variant gene 1

Synonyms

ER81; Etsrp81

Species

Mus musculus

Ensembl Gene

ENSMUSG00000004151

Encoded Proteins

IDBP-136025

ets variant gene 1

IDBP-531564

ets variant gene 1

IDBP-537117

ets variant gene 1

IDBP-541760

ets variant gene 1

IDBP-535540

ets variant gene 1

IDBP-541267

ets variant gene 1

IDBP-533530

ets variant gene 1

IDBP-541560

ets variant gene 1

IDBP-539588

ets variant gene 1

IDBP-534019

ets variant gene 1

IDBP-534976

ets variant gene 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006468:
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA[AT]-3'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5\'-CGGA[AT]-3\'. The protein encoded by this gene contains a conserved short acidic transactivation domain (TAD) in the N-terminal region, in addition to the ETS DNA-binding domain in the C-terminal region. This gene is involved in chromosomal translocations, which result in multiple fusion proteins including EWS-ETV1 in Erwing sarcoma and at least 10 ETV1 partners (see PMID: 19657377, Table 1) in prostate cancer. In addition to chromosomal rearrangement, this gene is overexpressed in prostate cancer, melanoma and gastrointestinal stromal tumor. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:38779380-38868215

Strand

Forward strand

Band

Transcripts

ENSMUST00000095767	ENSMUSP00000093442
ENSMUST00000160244	ENSMUSP00000125733
ENSMUST00000162563	ENSMUSP00000125157
ENSMUST00000161164	ENSMUSP00000124650
ENSMUST00000160996	ENSMUSP00000124705
ENSMUST00000160856	ENSMUSP00000125692
ENSMUST00000162730
ENSMUST00000161513	ENSMUSP00000124166
ENSMUST00000161980	ENSMUSP00000124736
ENSMUST00000160701	ENSMUSP00000124019
ENSMUST00000159334	ENSMUSP00000125676
ENSMUST00000163063	ENSMUSP00000124964
ENSMUST00000161591

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007411	axon guidance
GO:0007517	muscle organ development
GO:0007638	mechanosensory behavior
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005634

nucleus

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000006468

View Gene Order

ENSBTAG00000015981

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

p38_mk2pathway

p38 signaling mediated by MAPKAP kinases

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.472994 Mm.473557 Mm.484256

RefSeq

NM_001163154 NM_007960 XM_006514964 XM_006514965 XM_006514968 XM_006514972 XM_484312

OMIM

CCDS

CCDS49053 CCDS49054

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas