InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Etv1

Summary

InnateDB Protein

IDBP-136025.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Etv1

Protein Name

ets variant gene 1

Synonyms

ER81; Etsrp81;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000093442

InnateDB Gene

IDBG-136023 (Etv1)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3'.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Abundant in kidney. Moderate levels seen in the heart, brain, lung, embryo and lower levels seen in spleen, intestine, testis and thymus.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0007411	axon guidance
GO:0007517	muscle organ development
GO:0007638	mechanosensory behavior
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter