InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Qk

Summary

InnateDB Gene

IDBG-136170.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gene Name

quaking

Synonyms

1110003F05Rik; 1500005P18; l(17)-1Wis; l17Wis1; QkI

Species

Mus musculus

Ensembl Gene

ENSMUSG00000062078

Encoded Proteins

IDBP-136172

quaking

IDBP-136174

quaking

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112531:
The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Four transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]
The protein encoded by this gene is an RNA-binding protein that regulates pre-mRNA splicing, export of mRNAs from the nucleus, protein translation, and mRNA stability. The encoded protein is involved in myelinization and oligodendrocyte differentiation and may play a role in schizophrenia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:10206471-10319361

Strand

Reverse strand

Band

Transcripts

ENSMUST00000097414	ENSMUSP00000095025
ENSMUST00000042296	ENSMUSP00000046740

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 45 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	23 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	45 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0017124	SH3 domain binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001570	vasculogenesis
GO:0006397	mRNA processing
GO:0006417	regulation of translation
GO:0007286	spermatid development
GO:0008366	axon ensheathment
GO:0008380	RNA splicing
GO:0010628	positive regulation of gene expression
GO:0042552	myelination
GO:0042692	muscle cell differentiation
GO:0042759	long-chain fatty acid biosynthetic process
GO:0051028	mRNA transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000112531

View Gene Order

ENSBTAG00000011593

Not yet available

Cross-References

SwissProt

Q9QYS9

TrEMBL

Q3UQQ1

UniProt Splice Variant

Entrez Gene

19317

UniGene

Mm.340470 Mm.398000 Mm.398215 Mm.431520 Mm.473006 Mm.473223 Mm.476212

RefSeq

NM_001159516 NM_001159517 NM_021881

OMIM

CCDS

CCDS28387 CCDS49947

HPRD

IMGT

MGI ID

MGI:97837

MGI Symbol

EMBL

AF090392 AF090393 AF090394 AF090395 AF090396 AF090397 AF090400 AF090401 AF090402 AF090403 AF090404 AF091047 AF467890 AJ012812 AJ012813 AJ012814 AJ012815 AJ012816 AJ012817 AJ012818 AJ012819 AJ012820 AK005169 AK132303 AK142236 BC053426 BC056346 U44940

GenPept

AAC52491 AAC63042 AAC99452 AAC99453 AAC99454 AAD53329 AAD53330 AAD53331 AAD53332 AAH53426 AAH56346 AAM21006 AAM21007 AAM21008 AAM21009 AAM21010 BAB23859 BAE21091 BAE24988 CAB37614 CAB37615 CAB37616

RNA Seq Atlas

19317