Version 5.4
Mus musculus Gene: Tsen34
Summary
InnateDB Gene IDBG-136233.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tsen34
Gene Name tRNA splicing endonuclease 34 homolog (S. cerevisiae)
Synonyms 0610027F08Rik; Leng5
Species Mus musculus
Ensembl Gene ENSMUSG00000035585
Encoded Proteins
IDBP-136235
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
IDBP-264133
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
IDBP-264135
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
IDBP-264137
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
IDBP-532155
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
IDBP-536093
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
IDBP-536465
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
IDBP-542457
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170892:
This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:3693375-3701023
Strand Forward strand
Band A1
Transcripts
ENSMUST00000038521 ENSMUSP00000046911
ENSMUST00000108630 ENSMUSP00000104270
ENSMUST00000108629 ENSMUSP00000104269
ENSMUST00000108627 ENSMUSP00000104267
ENSMUST00000123088 ENSMUSP00000123614
ENSMUST00000142713 ENSMUSP00000118440
ENSMUST00000137204 ENSMUSP00000120403
ENSMUST00000155060 ENSMUSP00000118816
ENSMUST00000139396
ENSMUST00000147288
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000213 tRNA-intron endonuclease activity
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0000379 tRNA-type intron splice site recognition and cleavage
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006397 mRNA processing
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0000214 tRNA-intron endonuclease complex
GO:0005575 cellular_component
GO:0005730 nucleolus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000170892
View Gene Order
ENSBTAG00000006486
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.379100 Mm.474034
RefSeq NM_001164204 NM_001164205 NM_024168 XM_006540281 XM_006540283 XM_006540284 XM_006540285
OMIM
CCDS CCDS20725 CCDS51966
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca