Version 5.4
Homo sapiens Gene: TSEN34
Summary
InnateDB Gene IDBG-68287.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSEN34
Gene Name tRNA splicing endonuclease 34 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170892
Encoded Proteins
IDBP-68289
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
IDBP-237606
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
IDBP-237608
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
IDBP-384643
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
IDBP-384645
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
IDBP-384649
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a catalytic subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from precursor tRNAs. The endonuclease complex is also associated with a pre-mRNA 3-prime end processing factor. A mutation in this gene results in the neurological disorder pontocerebellar hypoplasia type 2. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:54189938-54194536
Strand Forward strand
Band q13.42
Transcripts
ENST00000302937 ENSP00000305524
ENST00000396388 ENSP00000379671
ENST00000396383 ENSP00000379667
ENST00000455798 ENSP00000400743
ENST00000456872 ENSP00000408689
ENST00000429671 ENSP00000397402
ENST00000496583
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
Experimentally validated
Total 18 [view]
Protein-Protein 14 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000213 tRNA-intron endonuclease activity
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0016829 lyase activity
Biological Process
GO:0000379 tRNA-type intron splice site recognition and cleavage
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006397 mRNA processing
GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic
Cellular Component
GO:0000214 tRNA-intron endonuclease complex
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035585
View Gene Order
ENSBTAG00000006486
Not yet available
Cross-References
SwissProt Q9BSV6
TrEMBL A0A024R4N9 B0V3J0
UniProt Splice Variant
Entrez Gene 79042
UniGene Hs.15580
RefSeq NM_024075 XM_005277087 XM_005277276 XM_005278290 NM_001077446 NM_001282332 NM_001282333
HUGO HGNC:15506
OMIM 608754
CCDS CCDS42609 CCDS74446
HPRD 10038
IMGT
EMBL AC012314 AK025929 BC004530 BC020805 CH471135 CU151838 CU457734
GenPept AAH04530 AAH20805 BAB15284 CAP19124 CAQ09596 EAW72203 EAW72205 EAW72207
RNA Seq Atlas 79042

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca