Version 5.4
Mus musculus Gene: Lilrb3
Summary
InnateDB Gene IDBG-136357.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lilrb3
Gene Name leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
Synonyms Gp91; Lilrb3; LIR-3; PIR-B
Species Mus musculus
Ensembl Gene ENSMUSG00000058818
Encoded Proteins
IDBP-136359
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20398663
Lilrb3 negatively regulates macrophage functions in response to pathogenic bacteria and chronic intestinal inflammatory responses, as demonstrated by increased production of proinflammatory cytokines (IL-6, IL-1beta and TNF-alpha) and activation of MAPK and NFkappaB in Lilrb3(-/-) macrophages following bacterial activation.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 7:3711409-3720391
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000078451 ENSMUSP00000077546
ENSMUST00000136238
ENSMUST00000155131
ENSMUST00000129493
ENSMUST00000137474
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001782 B cell homeostasis
GO:0019221 cytokine-mediated signaling pathway
GO:0019724 B cell mediated immunity
GO:0043011 myeloid dendritic cell differentiation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu04662
B cell receptor signaling pathway pathway
mmu04380
Osteoclast differentiation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.440814
RefSeq NM_011095 XM_006539633
OMIM
CCDS CCDS39730
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca