InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lilrb3

Summary

InnateDB Protein

IDBP-136359.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lilrb3

Protein Name

leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3

Synonyms

Gp91; Lilrb3; LIR-3; PIR-B;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000077546

InnateDB Gene

IDBG-136357 (Lilrb3)

Protein Structure

UniProt Annotation

Function

May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B- cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). {ECO:0000269PubMed:10327049, ECO:0000269PubMed:10611342, ECO:0000269PubMed:9482905}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:10327049, ECO:0000269PubMed:9054430, ECO:0000269PubMed:9482905}; Single- pass type I membrane protein {ECO:0000269PubMed:10327049, ECO:0000269PubMed:9054430, ECO:0000269PubMed:9482905}.

Disease Associations

Tissue Specificity

Detected in macrophages, splenocytes and B lymphocytes (at protein level). Detected in macrophages, mast cells, splenocytes, peritoneal cells and natural killer cells. {ECO:0000269PubMed:10611342, ECO:0000269PubMed:9054430}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0001782	B cell homeostasis
GO:0019221	cytokine-mediated signaling pathway
GO:0019724	B cell mediated immunity
GO:0043011	myeloid dendritic cell differentiation
GO:0045087	innate immune response (InnateDB)