Version 5.4
Mus musculus Gene: Arhgef10
Summary
InnateDB Gene IDBG-136428.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arhgef10
Gene Name Rho guanine nucleotide exchange factor (GEF) 10
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000071176
Encoded Proteins
IDBP-136430
Rho guanine nucleotide exchange factor (GEF) 10
IDBP-259466
Rho guanine nucleotide exchange factor (GEF) 10
IDBP-541368
Rho guanine nucleotide exchange factor (GEF) 10
IDBP-542067
Rho guanine nucleotide exchange factor (GEF) 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104728:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:14911663-15001085
Strand Forward strand
Band A1.1
Transcripts
ENSMUST00000084207 ENSMUSP00000081225
ENSMUST00000110800 ENSMUSP00000106424
ENSMUST00000160619
ENSMUST00000161162 ENSMUSP00000125606
ENSMUST00000163062 ENSMUSP00000125526
ENSMUST00000162444
ENSMUST00000162636
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0019894 kinesin binding
Biological Process
GO:0022011 myelination in peripheral nervous system
GO:0032319 regulation of Rho GTPase activity
GO:0033126 positive regulation of GTP catabolic process
GO:0035023 regulation of Rho protein signal transduction
GO:0051298 centrosome duplication
GO:0051496 positive regulation of stress fiber assembly
GO:0090307 spindle assembly involved in mitosis
Cellular Component
GO:0005813 centrosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104728
View Gene Order
ENSBTAG00000008585
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt
TrEMBL F7BCP8
UniProt Splice Variant
Entrez Gene 234094
UniGene Mm.240298
RefSeq NM_001037736 NM_172751 XM_006508766 XM_006508769
OMIM
CCDS CCDS40240 CCDS40241
HPRD
IMGT
MGI ID MGI:2444453
MGI Symbol Arhgef10
EMBL AC108844 AC124604
GenPept
RNA Seq Atlas 234094

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca