InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Bclaf1

Summary

InnateDB Gene

IDBG-136486.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bclaf1

Gene Name

BCL2-associated transcription factor 1

Synonyms

2610102K23Rik; 2700025J07Rik; 2810454G14Rik; 5730534O06Rik; AI450190; AW556225; Btf; mKIAA0164

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037608

Encoded Proteins

IDBP-136488

BCL2-associated transcription factor 1

IDBP-136490

BCL2-associated transcription factor 1

IDBP-787569

BCL2-associated transcription factor 1

IDBP-787573

BCL2-associated transcription factor 1

IDBP-787574

BCL2-associated transcription factor 1

IDBP-787575

BCL2-associated transcription factor 1

IDBP-787576

BCL2-associated transcription factor 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000029363:
This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:20312469-20344613

Strand

Forward strand

Band

Transcripts

ENSMUST00000043881	ENSMUSP00000043583
ENSMUST00000092678	ENSMUSP00000090349
ENSMUST00000186100	ENSMUSP00000140101
ENSMUST00000187338
ENSMUST00000190156	ENSMUSP00000140428
ENSMUST00000185800	ENSMUSP00000140623
ENSMUST00000191438	ENSMUSP00000140702
ENSMUST00000189158	ENSMUSP00000140608
ENSMUST00000191143
ENSMUST00000188546

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	15 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0043065	positive regulation of apoptotic process
GO:0043620	regulation of DNA-dependent transcription in response to stress
GO:0045892	negative regulation of transcription, DNA-templated
GO:2000144	positive regulation of DNA-dependent transcription, initiation
GO:2001022	positive regulation of response to DNA damage stimulus
GO:2001244	positive regulation of intrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000029363

View Gene Order

ENSBTAG00000007802

Not yet available

Cross-References

SwissProt

Q8K019

TrEMBL

F8WI22 Q3TEQ0 Q3TRC6 Q3UR37

UniProt Splice Variant

Entrez Gene

72567

UniGene

Mm.294783 Mm.404076

RefSeq

NM_001025392 NM_001025393 NM_153787 XM_006512865 XM_006512866

OMIM

CCDS

CCDS23721 CCDS35858

HPRD

IMGT

MGI ID

MGI:1917580

MGI Symbol

Bclaf1

EMBL

AC153845 AK011802 AK079110 AK088741 AK129071 AK141834 AK162896 AK169491 BC034300

GenPept

AAH34300 BAB27851 BAC37542 BAC40542 BAC97881 BAE24851 BAE37104 BAE41198

RNA Seq Atlas

72567