Mus musculus Gene: Mcm3 | |||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-136642.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Mcm3 | ||||||||||||||||||||||
Gene Name | minichromosome maintenance deficient 3 (S. cerevisiae) | ||||||||||||||||||||||
Synonyms | AL033361; C80350; Mcmd; P1; p1.m | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000041859 | ||||||||||||||||||||||
Encoded Proteins |
minichromosome maintenance deficient 3 (S. cerevisiae)
|
||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112118:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012] |
||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 1:20802968-20820312 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | A4 | ||||||||||||||||||||||
Transcripts |
|
||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 93 interaction(s) predicted by orthology.
|
||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||
Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Cell Cycle, Mitotic pathway
Synthesis of DNA pathway
DNA strand elongation pathway
DNA Replication pathway
Unwinding of DNA pathway
Switching of origins to a post-replicative state pathway
Cell Cycle pathway
Cell Cycle Checkpoints pathway
Regulation of DNA replication pathway
Activation of the pre-replicative complex pathway
Orc1 removal from chromatin pathway
M/G1 Transition pathway
G2/M Checkpoints pathway
G1/S Transition pathway
Removal of licensing factors from origins pathway
Mitotic G1-G1/S phases pathway
Activation of ATR in response to replication stress pathway
DNA Replication Pre-Initiation pathway
Assembly of the pre-replicative complex pathway
S Phase pathway
|
||||||||||||||||||||||
KEGG |
DNA replication pathway
Cell cycle pathway
|
||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Activation of ATR in response to replication stress pathway
Orc1 removal from chromatin pathway
Removal of licensing factors from origins pathway
Switching of origins to a post-replicative state pathway
Unwinding of DNA pathway
Activation of the pre-replicative complex pathway
Assembly of the pre-replicative complex pathway
DNA Replication pathway
Synthesis of DNA pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G2/M Checkpoints pathway
DNA Replication Pre-Initiation pathway
G1/S Transition pathway
Cell Cycle pathway
M/G1 Transition pathway
Cell Cycle, Mitotic pathway
DNA strand elongation pathway
Regulation of DNA replication pathway
Cell Cycle Checkpoints pathway
|
||||||||||||||||||||||
KEGG |
DNA replication pathway
Cell cycle pathway
|
||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI |
E2F transcription factor network
|
||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | NM_008563 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS14843 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||