InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mcm3

Summary

InnateDB Gene

IDBG-136642.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mcm3

Gene Name

minichromosome maintenance deficient 3 (S. cerevisiae)

Synonyms

AL033361; C80350; Mcmd; P1; p1.m

Species

Mus musculus

Ensembl Gene

ENSMUSG00000041859

Encoded Proteins

IDBP-136644

minichromosome maintenance deficient 3 (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112118:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with and is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:20802968-20820312

Strand

Reverse strand

Band

Transcripts

ENSMUST00000053266	ENSMUSP00000059192
ENSMUST00000185296
ENSMUST00000188112
ENSMUST00000191061
ENSMUST00000190421

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 93 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	93 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016851	magnesium chelatase activity
GO:0017111	nucleoside-triphosphatase activity

Biological Process

GO:0006260	DNA replication
GO:0006270	DNA replication initiation
GO:0007049	cell cycle
GO:0015979	photosynthesis
GO:0015995	chlorophyll biosynthetic process
GO:0032508	DNA duplex unwinding

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0016020	membrane
GO:0042555	MCM complex
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm