InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Actl6a

Summary

InnateDB Gene

IDBG-136942.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Actl6a

Gene Name

actin-like 6A

Synonyms

2810432C06Rik; Actl6; AI851094; ARP4; Baf53a; C79802

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027671

Encoded Proteins

IDBP-136944

actin-like 6A

IDBP-532246

actin-like 6A

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136518:
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:32708546-32726968

Strand

Forward strand

Band

Transcripts

ENSMUST00000029214	ENSMUSP00000029214
ENSMUST00000126144	ENSMUSP00000114317
ENSMUST00000135400
ENSMUST00000153779

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0031492	nucleosomal DNA binding

Biological Process

GO:0003407	neural retina development
GO:0006281	DNA repair
GO:0006310	DNA recombination
GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007399	nervous system development
GO:0040008	regulation of growth
GO:0043044	ATP-dependent chromatin remodeling
GO:0043967	histone H4 acetylation
GO:0043968	histone H2A acetylation

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0016514	SWI/SNF complex
GO:0031011	Ino80 complex
GO:0035267	NuA4 histone acetyltransferase complex
GO:0043234	protein complex
GO:0071564	npBAF complex