Bos taurus Gene: ACTL6A | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-635993.3 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | ACTL6A | ||||||||||||||||
Gene Name | actin-like protein 6A | ||||||||||||||||
Synonyms | |||||||||||||||||
Species | Bos taurus | ||||||||||||||||
Ensembl Gene | ENSBTAG00000002460 | ||||||||||||||||
Encoded Proteins |
actin-like protein 6A
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
Entrez Gene | |||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136518:
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 1:88129517-88160918 | ||||||||||||||||
Strand | Reverse strand | ||||||||||||||||
Band | |||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Homo sapiens
Mus musculus
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Gene ID
Gene Order
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Pathway Predictions based on Human Orthology Data | |||||||||||||||||
NETPATH |
TNFalpha pathway
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REACTOME |
HATs acetylate histones pathway
Chromatin organization pathway
RMTs methylate histone arginines pathway
Chromatin modifying enzymes pathway
Chromatin organization pathway
HATs acetylate histones pathway
Chromatin modifying enzymes pathway
RMTs methylate histone arginines pathway
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KEGG | |||||||||||||||||
INOH | |||||||||||||||||
PID NCI |
Validated targets of C-MYC transcriptional activation
C-MYC pathway
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Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | A4IFJ8 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 100125416 | ||||||||||||||||
UniGene | Bt.80045 | ||||||||||||||||
RefSeq | NM_001105035 XM_005201638 XM_005201639 | ||||||||||||||||
HUGO | |||||||||||||||||
OMIM | |||||||||||||||||
CCDS | |||||||||||||||||
HPRD | |||||||||||||||||
IMGT | |||||||||||||||||
EMBL | BC134613 DAAA02001958 | ||||||||||||||||
GenPept | AAI34614 | ||||||||||||||||
RNA Seq Atlas | 100125416 | ||||||||||||||||