InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Itga8

Summary

InnateDB Gene

IDBG-137042.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Itga8

Gene Name

integrin alpha 8

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000026768

Encoded Proteins

IDBP-137044

integrin alpha 8

IDBP-624997

integrin alpha 8

IDBP-624996

integrin alpha 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077943:
Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:12106632-12301920

Strand

Reverse strand

Band

Transcripts

ENSMUST00000028106	ENSMUSP00000028106
ENSMUST00000148055	ENSMUSP00000134238
ENSMUST00000129370
ENSMUST00000141477
ENSMUST00000130548
ENSMUST00000172791	ENSMUSP00000134154
ENSMUST00000172716

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0046872	metal ion binding

Biological Process

GO:0001656	metanephros development
GO:0007155	cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007420	brain development
GO:0007613	memory
GO:0030030	cell projection organization
GO:0030198	extracellular matrix organization
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0042472	inner ear morphogenesis
GO:0045184	establishment of protein localization
GO:0048745	smooth muscle tissue development
GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation

Cellular Component

GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0014069	postsynaptic density
GO:0032591	dendritic spine membrane
GO:0043204	perikaryon
GO:0045177	apical part of cell