InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ROCK1

Summary

InnateDB Gene

IDBG-1371.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ROCK1

Gene Name

Rho-associated, coiled-coil containing protein kinase 1

Synonyms

P160ROCK; ROCK-I

Species

Homo sapiens

Ensembl Gene

ENSG00000067900

Encoded Proteins

IDBP-229749

Rho-associated, coiled-coil containing protein kinase 1

IDBP-728191

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:20946906-21111851

Strand

Reverse strand

Band

q11.1

Transcripts

ENST00000399799	ENSP00000382697
ENST00000578051	ENSP00000462004
ENST00000584875
ENST00000584687
ENST00000583556
ENST00000582445

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	36 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0017048	Rho GTPase binding
GO:0046872	metal ion binding

Biological Process

GO:0003383	apical constriction
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0006921	cellular component disassembly involved in execution phase of apoptosis
GO:0006939	smooth muscle contraction
GO:0007159	leukocyte cell-cell adhesion
GO:0007165	signal transduction
GO:0007266	Rho protein signal transduction
GO:0007411	axon guidance
GO:0016525	negative regulation of angiogenesis
GO:0022614	membrane to membrane docking
GO:0030036	actin cytoskeleton organization
GO:0030155	regulation of cell adhesion
GO:0032060	bleb assembly
GO:0032956	regulation of actin cytoskeleton organization
GO:0032970	regulation of actin filament-based process
GO:0035556	intracellular signal transduction
GO:0043524	negative regulation of neuron apoptotic process
GO:0045616	regulation of keratinocyte differentiation
GO:0050900	leukocyte migration
GO:0050901	leukocyte tethering or rolling
GO:0051451	myoblast migration
GO:0051492	regulation of stress fiber assembly
GO:0051893	regulation of focal adhesion assembly
GO:0051894	positive regulation of focal adhesion assembly
GO:2000114	regulation of establishment of cell polarity
GO:2000145	regulation of cell motility

Cellular Component

GO:0000139	Golgi membrane
GO:0001726	ruffle
GO:0005814	centriole
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0030027	lamellipodium
GO:0032059	bleb