Version 5.4
Bos taurus Gene: ROCK1
Summary
InnateDB Gene IDBG-644080.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ROCK1
Gene Name Rho-associated protein kinase 1
Synonyms p160ROCK; ROCK-I
Species Bos taurus
Ensembl Gene ENSBTAG00000008403
Encoded Proteins
IDBP-696690
Rho-associated, coiled-coil containing protein kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067900:
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 24:35445610-35519082
Strand Forward strand
Band
Transcripts
ENSBTAT00000061061 ENSBTAP00000053818
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0017048 Rho GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0003383 apical constriction
GO:0006468 protein phosphorylation
GO:0007159 leukocyte cell-cell adhesion
GO:0007165 signal transduction
GO:0016310 phosphorylation
GO:0016525 negative regulation of angiogenesis
GO:0022614 membrane to membrane docking
GO:0030036 actin cytoskeleton organization
GO:0032060 bleb assembly
GO:0032970 regulation of actin filament-based process
GO:0035556 intracellular signal transduction
GO:0043524 negative regulation of neuron apoptotic process
GO:0045616 regulation of keratinocyte differentiation
GO:0050900 leukocyte migration
GO:0050901 leukocyte tethering or rolling
GO:0051451 myoblast migration
GO:0051894 positive regulation of focal adhesion assembly
Cellular Component
GO:0001726 ruffle
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0030027 lamellipodium
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000067900
View Gene Order
ENSMUSG00000024290
View Gene Order
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_18407
G alpha (12/13) signalling events pathway
REACT_107
Apoptotic cleavage of cellular proteins pathway
REACT_995
Apoptotic execution phase pathway
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_111045
Developmental Biology pathway
REACT_19271
Semaphorin interactions pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_12529
Signaling by VEGF pathway
REACT_14797
Signaling by GPCR pathway
REACT_18266
Axon guidance pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_228063
EPHA-mediated growth cone collapse pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_258521
Apoptosis pathway
REACT_223625
GPCR downstream signaling pathway
REACT_254215
Signaling by GPCR pathway
REACT_227951
Signaling by VEGF pathway
REACT_243939
EPHA-mediated growth cone collapse pathway
REACT_224460
Apoptotic cleavage of cellular proteins pathway
REACT_246650
Sema4D induced cell migration and growth-cone collapse pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_204733
G alpha (12/13) signalling events pathway
REACT_257656
EPHB-mediated forward signaling pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_234744
Sema4D in semaphorin signaling pathway
REACT_188576
Developmental Biology pathway
REACT_263034
Semaphorin interactions pathway
REACT_188257
Signal Transduction pathway
REACT_207035
Apoptotic execution phase pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04350
TGF-beta signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04510
Focal adhesion pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04062
Chemokine signaling pathway pathway
hsa05131
Shigellosis pathway
mmu04360
Axon guidance pathway
mmu04350
TGF-beta signaling pathway pathway
mmu04810
Regulation of actin cytoskeleton pathway
mmu04670
Leukocyte transendothelial migration pathway
mmu04510
Focal adhesion pathway
mmu04062
Chemokine signaling pathway pathway
mmu04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
epha_fwdpathway
EPHA forward signaling
txa2pathway
Thromboxane A2 receptor signaling
avb3_integrin_pathway
Integrins in angiogenesis
ephbfwdpathway
EPHB forward signaling
prlsignalingeventspathway
Signaling events mediated by PRL
vegfr1_2_pathway
Signaling events mediated by VEGFR1 and VEGFR2
wnt_noncanonical_pathway
Noncanonical Wnt signaling pathway
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
amb2_neutrophils_pathway
amb2 Integrin signaling
ncadherinpathway
N-cadherin signaling events
Cross-References
SwissProt
TrEMBL F1MF50
UniProt Splice Variant
Entrez Gene 785911
UniGene Bt.111558 Bt.112026 Bt.65075
RefSeq XM_003583969
HUGO HGNC:10251
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02056649 DAAA02056650 DAAA02056651 DAAA02056652
GenPept
RNA Seq Atlas 785911

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca