Version 5.4
Mus musculus Gene: Sgk1
Summary
InnateDB Gene IDBG-137283.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sgk1
Gene Name serum/glucocorticoid regulated kinase 1
Synonyms Sgk
Species Mus musculus
Ensembl Gene ENSMUSG00000019970
Encoded Proteins
IDBP-137285
serum/glucocorticoid regulated kinase 1
IDBP-137287
serum/glucocorticoid regulated kinase 1
IDBP-137289
serum/glucocorticoid regulated kinase 1
IDBP-401614
serum/glucocorticoid regulated kinase 1
IDBP-539909
serum/glucocorticoid regulated kinase 1
IDBP-542106
serum/glucocorticoid regulated kinase 1
IDBP-539170
serum/glucocorticoid regulated kinase 1
IDBP-531889
serum/glucocorticoid regulated kinase 1
IDBP-628165
serum/glucocorticoid regulated kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. This enzyme is activated by protein phosphorylation and degraded via the ubiquitination and proteasome pathway. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene was identified on chromosome 12. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:21882184-21999903
Strand Forward strand
Band A3
Transcripts
ENSMUST00000100036 ENSMUSP00000097614
ENSMUST00000092673 ENSMUSP00000090343
ENSMUST00000020145 ENSMUSP00000020145
ENSMUST00000120509 ENSMUSP00000114074
ENSMUST00000143094
ENSMUST00000124203 ENSMUSP00000116096
ENSMUST00000142174 ENSMUSP00000120882
ENSMUST00000150089 ENSMUSP00000115073
ENSMUST00000141218
ENSMUST00000126560
ENSMUST00000124350 ENSMUSP00000114691
ENSMUST00000135195
ENSMUST00000164659 ENSMUSP00000128873
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 79 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 79 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0006468 protein phosphorylation
GO:0006915 apoptotic process
GO:0006974 cellular response to DNA damage stimulus
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000118515
View Gene Order
ENSBTAG00000004269
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
KEGG
mmu04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_14
IL2 pathway
NetPath_18
IL6 pathway
NetPath_25
FSH pathway
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
REACT_223895
Ion channel transport pathway
REACT_223103
Transmembrane transport of small molecules pathway
REACT_213748
Stimuli-sensing channels pathway
KEGG
hsa04960
Aldosterone-regulated sodium reabsorption pathway
INOH
PID NCI
pi3kcipathway
Class I PI3K signaling events
mtor_4pathway
mTOR signaling pathway
foxopathway
FoxO family signaling
reg_gr_pathway
Glucocorticoid receptor regulatory network
insulin_pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.28405
RefSeq NM_001161845 NM_001161847 NM_001161848 NM_001161849 NM_001161850 NM_011361
OMIM
CCDS CCDS23726 CCDS48515 CCDS48516 CCDS48517 CCDS48518
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca