InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: SGK1

Summary

InnateDB Gene

IDBG-633483.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SGK1

Gene Name

Serine/threonine-protein kinase Sgk1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004269

Encoded Proteins

IDBP-685199

Serine/threonine-protein kinase Sgk1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000118515:
This gene encodes a serine/threonine protein kinase that plays an important role in cellular stress response. This kinase activates certain potassium, sodium, and chloride channels, suggesting an involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion. High levels of expression of this gene may contribute to conditions such as hypertension and diabetic nephropathy. Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:73305313-73310869

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000005592

ENSBTAP00000005592

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 77 interaction(s) predicted by orthology.

Predicted by orthology
Total	77 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004712	protein serine/threonine/tyrosine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0006974	cellular response to DNA damage stimulus
GO:0016310	phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0016020	membrane