Mus musculus Gene: Il13ra1
Summary
InnateDB Gene IDBG-137900.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il13ra1
Gene Name interleukin 13 receptor, alpha 1
Synonyms AI882074; CD213a1; IL-13r[a]; Il13ra; NR4
Species Mus musculus
Ensembl Gene ENSMUSG00000017057
Encoded Proteins
interleukin 13 receptor, alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] IL13RA1 is a receptor for IL13. Upon ligand engagement, IL13RA1 activates the transcription factor STAT6 to induce M2 expression profile in macrophages.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131724:
The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:36112110-36171259
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000033418 ENSMUSP00000033418
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016515 interleukin-13 receptor activity
Biological Process
GO:0002639 positive regulation of immunoglobulin production
GO:0030890 positive regulation of B cell proliferation
GO:0035772 interleukin-13-mediated signaling pathway
Cellular Component
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
INOH
JAK STAT pathway and regulation pathway
IL-13 signaling pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
IL4 pathway
REACTOME
KEGG
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
INOH
JAK STAT pathway and regulation pathway
IL-13 signaling pathway
PID NCI
IL4-mediated signaling events
Cross-References
SwissProt O09030
TrEMBL
UniProt Splice Variant
Entrez Gene 16164
UniGene Mm.24208 Mm.404224
RefSeq NM_133990
OMIM
CCDS CCDS30057
HPRD
IMGT
MGI ID MGI:105052
MGI Symbol Il13ra1
EMBL BC052425 BC059939 S80963
GenPept AAB50695 AAH52425 AAH59939
RNA Seq Atlas 16164