InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il13ra1

Summary

InnateDB Protein

IDBP-137902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il13ra1

Protein Name

interleukin 13 receptor, alpha 1

Synonyms

AI882074; CD213a1; IL-13r[a]; Il13ra; NR4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033418

InnateDB Gene

IDBG-137900 (Il13ra1)

Protein Structure

UniProt Annotation

Function

Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Spleen, liver, thymus, heart, lung, kidney, testis, stomach, brain, skin, and colon; but not skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016515	interleukin-13 receptor activity

Biological Process

GO:0002639	positive regulation of immunoglobulin production
GO:0030890	positive regulation of B cell proliferation
GO:0035772	interleukin-13-mediated signaling pathway