Mus musculus Gene: Dlg5
Summary
InnateDB Gene IDBG-138094.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dlg5
Gene Name discs, large homolog 5 (Drosophila)
Synonyms 4933429D20Rik; mKIAA0583; T25557
Species Mus musculus
Ensembl Gene ENSMUSG00000021782
Encoded Proteins
discs, large homolog 5 (Drosophila)
discs, large homolog 5 (Drosophila)
discs, large homolog 5 (Drosophila)
discs, large homolog 5 (Drosophila)
discs, large homolog 5 (Drosophila)
discs, large homolog 5 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151208:
This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:24133953-24245920
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000090398 ENSMUSP00000087879
ENSMUST00000073687 ENSMUSP00000073367
ENSMUST00000042009 ENSMUSP00000044852
ENSMUST00000166007 ENSMUSP00000127054
ENSMUST00000170112 ENSMUSP00000128735
ENSMUST00000164638
ENSMUST00000167343
ENSMUST00000169880 ENSMUSP00000131986
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008092 cytoskeletal protein binding
Biological Process
GO:0006461 protein complex assembly
GO:0030859 polarized epithelial cell differentiation
GO:0030901 midbrain development
GO:0042981 regulation of apoptotic process
GO:0045176 apical protein localization
GO:0045186 zonula adherens assembly
GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0071896 protein localization to adherens junction
GO:0072205 metanephric collecting duct development
Cellular Component
GO:0005622 intracellular
GO:0005913 cell-cell adherens junction
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.473594 Mm.68971
RefSeq NM_001163513 NM_027726 XM_006519560 XM_006519561 XM_006519562 XM_006519564 XM_006519565
OMIM
CCDS CCDS49416 CCDS49417
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas