InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Vnn1

Summary

InnateDB Gene

IDBG-138104.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vnn1

Gene Name

vanin 1

Synonyms

V-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000037440

Encoded Proteins

IDBP-138106

vanin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112299:
This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:23894688-23905343

Strand

Forward strand

Band

Transcripts

ENSMUST00000041416

ENSMUSP00000040599

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017159	pantetheine hydrolase activity
GO:0034235	GPI anchor binding

Biological Process

GO:0002526	acute inflammatory response
GO:0002544	chronic inflammatory response
GO:0006807	nitrogen compound metabolic process
GO:0006954	inflammatory response
GO:0015939	pantothenate metabolic process
GO:0016337	single organismal cell-cell adhesion
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0045087	innate immune response
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031225	anchored component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000112299

View Gene Order

ENSBTAG00000015094

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu00770

Pantothenate and CoA biosynthesis pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa00770

Pantothenate and CoA biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

Q9Z0K8

TrEMBL

Q3UEK0

UniProt Splice Variant

Entrez Gene

22361

UniGene

Mm.27154

RefSeq

NM_011704 XM_006512718

OMIM

CCDS

CCDS35868

HPRD

IMGT

MGI ID

MGI:108395

MGI Symbol

Vnn1

EMBL

AJ132098 AK002773 AK145984 AK149485 AK167427 BC019203 CH466540

GenPept

AAH19203 BAB22347 BAE26806 BAE28911 BAE39515 CAA10567 EDL04771

RNA Seq Atlas

22361