InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VNN1

Summary

InnateDB Gene

IDBG-96670.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VNN1

Gene Name

vanin 1

Synonyms

HDLCQ8; Tiff66

Species

Homo sapiens

Ensembl Gene

ENSG00000112299

Encoded Proteins

IDBP-96672

vanin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:132681590-132714049

Strand

Reverse strand

Band

q23.2

Transcripts

ENST00000367928

ENSP00000356905

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017159	pantetheine hydrolase activity
GO:0034235	GPI anchor binding

Biological Process

GO:0002526	acute inflammatory response
GO:0002544	chronic inflammatory response
GO:0006807	nitrogen compound metabolic process
GO:0006928	cellular component movement
GO:0006954	inflammatory response
GO:0006979	response to oxidative stress
GO:0015939	pantothenate metabolic process
GO:0016337	single organismal cell-cell adhesion
GO:0033089	positive regulation of T cell differentiation in thymus
GO:0045087	innate immune response
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0031225	anchored component of membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000037440

View Gene Order

ENSBTAG00000015094

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00770

Pantothenate and CoA biosynthesis pathway

INOH

PID NCI

Cross-References

SwissProt

O95497

TrEMBL

UniProt Splice Variant

Entrez Gene

8876

UniGene

Hs.12114 Hs.701198

RefSeq

NM_004666

HUGO

HGNC:12705

OMIM

603570

CCDS

CCDS5159

HPRD

04651

IMGT

EMBL

AJ132099 AK290425 AL032821 BC096265 BC096266 BC096267 BC096268 DQ100297 U39664

GenPept

AAF21453 AAH96265 AAH96266 AAH96267 AAH96268 AAY88742 BAF83114 CAA10568 CAB40075

RNA Seq Atlas

8876