Mus musculus Gene: Stip1
Summary
InnateDB Gene IDBG-138159.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Stip1
Gene Name stress-induced phosphoprotein 1
Synonyms Hop; p60; Sti1
Species Mus musculus
Ensembl Gene ENSMUSG00000024966
Encoded Proteins
stress-induced phosphoprotein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168439:
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:7020696-7040026
Strand Reverse strand
Band A
Transcripts
ENSMUST00000025918 ENSMUSP00000025918
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 56 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 56 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
CHL1 interactions pathway
Axon guidance pathway
L1CAM interactions pathway
Developmental Biology pathway
KEGG
Prion diseases pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
KEGG
Prion diseases pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.258633
RefSeq NM_016737
OMIM
CCDS CCDS37901
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas