InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Dnajc2

Summary

InnateDB Gene

IDBG-138388.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dnajc2

Gene Name

DnaJ (Hsp40) homolog, subfamily C, member 2

Synonyms

AU020218; MIDA1; Zrf1; Zrf2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029014

Encoded Proteins

IDBP-138390

DnaJ (Hsp40) homolog, subfamily C, member 2

IDBP-250149

DnaJ (Hsp40) homolog, subfamily C, member 2

IDBP-250151

DnaJ (Hsp40) homolog, subfamily C, member 2

IDBP-250153

DnaJ (Hsp40) homolog, subfamily C, member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000105821:
This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:21757267-21785251

Strand

Reverse strand

Band

Transcripts

ENSMUST00000030771	ENSMUSP00000030771
ENSMUST00000115195	ENSMUSP00000110849
ENSMUST00000115193	ENSMUSP00000110847
ENSMUST00000115192	ENSMUSP00000110846
ENSMUST00000132962
ENSMUST00000145955
ENSMUST00000147987

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	3 [view]
Protein-DNA	8 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0030544	Hsp70 protein binding
GO:0042393	histone binding
GO:0043130	ubiquitin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006260	DNA replication
GO:0006351	transcription, DNA-templated
GO:0016568	chromatin modification
GO:0030308	negative regulation of cell growth
GO:0045893	positive regulation of transcription, DNA-templated
GO:2000279	negative regulation of DNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031965	nuclear membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000105821

View Gene Order

ENSBTAG00000003784

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.266312 Mm.442319

RefSeq

NM_009584 XM_006535679

OMIM

CCDS

CCDS19107

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas