Version 5.4
Homo sapiens Gene: DNAJC2
Summary
InnateDB Gene IDBG-34312.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAJC2
Gene Name DnaJ (Hsp40) homolog, subfamily C, member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000105821
Encoded Proteins
IDBP-34314
DnaJ (Hsp40) homolog, subfamily C, member 2
IDBP-34316
DnaJ (Hsp40) homolog, subfamily C, member 2
IDBP-34318
DnaJ (Hsp40) homolog, subfamily C, member 2
IDBP-384586
DnaJ (Hsp40) homolog, subfamily C, member 2
IDBP-384587
DnaJ (Hsp40) homolog, subfamily C, member 2
IDBP-384588
DnaJ (Hsp40) homolog, subfamily C, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:103312474-103344873
Strand Reverse strand
Band q22.1
Transcripts
ENST00000249270 ENSP00000249270
ENST00000379263 ENSP00000368565
ENST00000379257 ENSP00000368559
ENST00000426036 ENSP00000412611
ENST00000454277 ENSP00000399058
ENST00000412522 ENSP00000406275
ENST00000475065
ENST00000492497
ENST00000464253
ENST00000475090
ENST00000483637
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0030544 Hsp70 protein binding
GO:0042393 histone binding
GO:0043130 ubiquitin binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006260 DNA replication
GO:0006351 transcription, DNA-templated
GO:0016568 chromatin modification
GO:0030308 negative regulation of cell growth
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051083 'de novo' cotranslational protein folding
GO:2000279 negative regulation of DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029014
View Gene Order
ENSBTAG00000003784
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.558476 Hs.629124
RefSeq NM_001129887 NM_014377
HUGO
OMIM
CCDS CCDS43628 CCDS47679
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca