InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Braf

Summary

InnateDB Gene

IDBG-138657.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Braf

Gene Name

Braf transforming gene

Synonyms

9930012E13Rik; AA120551; AA387315; AA473386; B-raf; Braf-2; Braf2; C230098H17; C87398; D6Ertd631e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000002413

Encoded Proteins

IDBP-138659

Braf transforming gene

IDBP-138661

Braf transforming gene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000157764:
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:39603237-39725463

Strand

Reverse strand

Band

Transcripts

ENSMUST00000002487	ENSMUSP00000002487
ENSMUST00000101497	ENSMUSP00000099036
ENSMUST00000167073
ENSMUST00000167169
ENSMUST00000169647

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005057	receptor signaling protein activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0042802	identical protein binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0002318	myeloid progenitor cell differentiation
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0008542	visual learning
GO:0010628	positive regulation of gene expression
GO:0010764	negative regulation of fibroblast migration
GO:0030154	cell differentiation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035019	somatic stem cell maintenance
GO:0035556	intracellular signal transduction
GO:0035690	cellular response to drug
GO:0042127	regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043367	CD4-positive, alpha-beta T cell differentiation
GO:0043368	positive T cell selection
GO:0043434	response to peptide hormone
GO:0043524	negative regulation of neuron apoptotic process
GO:0046632	alpha-beta T cell differentiation
GO:0051291	protein heterooligomerization
GO:0051496	positive regulation of stress fiber assembly
GO:0051591	response to cAMP
GO:0060291	long-term synaptic potentiation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070849	response to epidermal growth factor
GO:0071277	cellular response to calcium ion
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
GO:2000301	negative regulation of synaptic vesicle exocytosis
GO:2000352	negative regulation of endothelial cell apoptotic process