InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Braf

Summary

InnateDB Protein

IDBP-138659.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Braf

Protein Name

Braf transforming gene

Synonyms

9930012E13Rik; AA120551; AA387315; AA473386; B-raf; Braf-2; Braf2; C230098H17; C87398; D6Ertd631e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000002487

InnateDB Gene

IDBG-138657 (Braf)

Protein Structure

UniProt Annotation

Function

Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. {ECO:0000250}.

Disease Associations

Note=Participates in a chromosomal translocation that produces a Tif1a-BRAF (T18) oncogene originally isolated from a furfural-induced hepatoma.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	49 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005057	receptor signaling protein activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0042802	identical protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0002318	myeloid progenitor cell differentiation
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0008542	visual learning
GO:0010628	positive regulation of gene expression
GO:0010764	negative regulation of fibroblast migration
GO:0030154	cell differentiation
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0035019	somatic stem cell maintenance
GO:0035556	intracellular signal transduction
GO:0035690	cellular response to drug
GO:0042127	regulation of cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0043367	CD4-positive, alpha-beta T cell differentiation
GO:0043368	positive T cell selection
GO:0043434	response to peptide hormone
GO:0043524	negative regulation of neuron apoptotic process
GO:0046632	alpha-beta T cell differentiation
GO:0051291	protein heterooligomerization
GO:0051496	positive regulation of stress fiber assembly
GO:0051591	response to cAMP
GO:0060291	long-term synaptic potentiation
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0070849	response to epidermal growth factor
GO:0071277	cellular response to calcium ion
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading
GO:2000301	negative regulation of synaptic vesicle exocytosis
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0043005	neuron projection
GO:0044297	cell body

Protein Structure and Domains

PDB ID

MGI:88190

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003116 Raf-like Ras-binding
IPR011009 Protein kinase-like domain
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR029071 Ubiquitin-related domain

PFAM

PF00069
PF07714
PF00130
PF02196

PRINTS

PR00109
PR00008

PIRSF

SMART

SM00109
SM00220
SM00455
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt