Version 5.4
Mus musculus Gene: Nkap
Summary
InnateDB Gene IDBG-138740.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nkap
Gene Name NFKB activating protein
Synonyms 2610020O08Rik; AA987160; AI849147; AL024236
Species Mus musculus
Ensembl Gene ENSMUSG00000016409
Encoded Proteins
IDBP-138742
NFKB activating protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000101882:
This gene encodes a protein that is involved in the activation of the ubiquitous transcription factor NF-kappaB. This protein is associated with the the histone deacetylase HDAC3 and with the Notch corepressor complex, and it thereby acts as a transcriptional repressor of Notch target genes. It is also required for alphabeta T cell development. A related pseudogene has been identified on chromosome X, while a related and intronless retrocopy, which has an intact CDS and may be functional, is located on chromosome 6. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:37126795-37150746
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000016553 ENSMUSP00000016553
ENSMUST00000152906
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0005515 protein binding
GO:0031490 chromatin DNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0007219 Notch signaling pathway
GO:0019827 stem cell maintenance
GO:0030097 hemopoiesis
GO:0030851 granulocyte differentiation
GO:0033077 T cell differentiation in thymus
GO:0045892 negative regulation of transcription, DNA-templated
GO:0046638 positive regulation of alpha-beta T cell differentiation
GO:0071425 hematopoietic stem cell proliferation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000101882
View Gene Order
ENSBTAG00000010884
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.407869 Mm.489882 Mm.55422
RefSeq NM_025937
OMIM
CCDS CCDS30069
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca