InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Nkap

Summary

InnateDB Protein

IDBP-138742.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Nkap

Protein Name

NFKB activating protein

Synonyms

2610020O08Rik; AA987160; AI849147; AL024236;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000016553

InnateDB Gene

IDBG-138740 (Nkap)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003682	chromatin binding
GO:0005515	protein binding
GO:0031490	chromatin DNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0007219	Notch signaling pathway
GO:0019827	stem cell maintenance
GO:0030097	hemopoiesis
GO:0030851	granulocyte differentiation
GO:0033077	T cell differentiation in thymus
GO:0045892	negative regulation of transcription, DNA-templated
GO:0046638	positive regulation of alpha-beta T cell differentiation
GO:0071425	hematopoietic stem cell proliferation