Version 5.4
Mus musculus Gene: Reln
Summary
InnateDB Gene IDBG-138749.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Reln
Gene Name reelin
Synonyms reeler; rl
Species Mus musculus
Ensembl Gene ENSMUSG00000042453
Encoded Proteins
IDBP-138751
reelin
IDBP-535904
reelin
IDBP-534691
reelin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000189056:
This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:21884454-22344702
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000062372 ENSMUSP00000058025
ENSMUST00000161356 ENSMUSP00000124052
ENSMUST00000160791
ENSMUST00000159768
ENSMUST00000161353
ENSMUST00000162427
ENSMUST00000159741
ENSMUST00000162876 ENSMUSP00000124077
ENSMUST00000162637
ENSMUST00000162622
ENSMUST00000160707
ENSMUST00000161782
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
GO:0070325 lipoprotein particle receptor binding
GO:0070326 very-low-density lipoprotein particle receptor binding
Biological Process
GO:0000904 cell morphogenesis involved in differentiation
GO:0001764 neuron migration
GO:0006508 proteolysis
GO:0007155 cell adhesion
GO:0007411 axon guidance
GO:0007417 central nervous system development
GO:0007420 brain development
GO:0007616 long-term memory
GO:0008306 associative learning
GO:0010001 glial cell differentiation
GO:0010468 regulation of gene expression
GO:0010976 positive regulation of neuron projection development
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016358 dendrite development
GO:0016477 cell migration
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021511 spinal cord patterning
GO:0021517 ventral spinal cord development
GO:0021766 hippocampus development
GO:0021800 cerebral cortex tangential migration
GO:0021819 layer formation in cerebral cortex
GO:0021987 cerebral cortex development
GO:0030900 forebrain development
GO:0032008 positive regulation of TOR signaling
GO:0032793 positive regulation of CREB transcription factor activity
GO:0035418 protein localization to synapse
GO:0038026 reelin-mediated signaling pathway
GO:0045860 positive regulation of protein kinase activity
GO:0048265 response to pain
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050795 regulation of behavior
GO:0050804 regulation of synaptic transmission
GO:0051057 positive regulation of small GTPase mediated signal transduction
GO:0051968 positive regulation of synaptic transmission, glutamatergic
GO:0061003 positive regulation of dendritic spine morphogenesis
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0090129 positive regulation of synapse maturation
GO:0097107 postsynaptic density assembly
GO:0097114 N-methyl-D-aspartate receptor clustering
GO:0097119 postsynaptic density protein 95 clustering
GO:0097120 receptor localization to synapse
GO:0097477 lateral motor column neuron migration
GO:1900273 positive regulation of long-term synaptic potentiation
GO:1902078 positive regulation of lateral motor column neuron migration
GO:2000310 regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
GO:2000969 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0030425 dendrite
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000189056
View Gene Order
ENSBTAG00000003658
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04512
ECM-receptor interaction pathway
mmu04510
Focal adhesion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
INOH
PID NCI
reelinpathway
Reelin signaling pathway
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.402938 Mm.425236
RefSeq NM_011261 XM_006535644 XM_006535645 XM_006535646
OMIM
CCDS CCDS39023
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca