InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Reln

Summary

InnateDB Protein

IDBP-535904.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Reln

Protein Name

reelin

Synonyms

reeler; rl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000124052

InnateDB Gene

IDBG-138749 (Reln)

Protein Structure

UniProt Annotation

Function

Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. {ECO:0000269PubMed:10880573}.

Subcellular Localization

Secreted, extracellular space, extracellular matrix.

Disease Associations

Note=Defects in Reln are the cause of the autosomal recessive reeler (rl) phenotype which is characterized by impaired motor coordination, tremors and ataxia. Neurons in affected mice fail to reach their correct locations in the developing brain, disrupting the organization of the cerebellar and cerebral cortices and other laminated regions.

Tissue Specificity

The major isoform 1 is neuron-specific. It is abundantly produced during brain ontogenesis by the Cajal-Retzius cells and other pioneer neurons located in the telencephalic marginal zone and by granule cells of the external granular layer of the cerebellum. Expression is located in deeper layers in the developing hippocampus and olfactory bulb, low levels of expression are also detected in the immature striatum. At early developmental stages, expressed also in hypothalamic differentiation fields, tectum and spinal cord. A moderate to low level of expression occurs in the septal area, striatal fields, habenular nuclei, some thalamic nuclei, particularly the lateral geniculate, the retina and some nuclei of the reticular formation in the central field of the medulla. Very low levels found in liver and kidney. No expression in radial glial cells, cortical plate, Purkinje cells and inferior olivary neurons. The minor isoform 2 is only expressed in non neuronal cells. The minor isoform 3 is found in the same cells as isoform 1, but is almost undetectable in retina and brain stem. {ECO:0000269PubMed:10328932, ECO:0000269PubMed:9182958}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008236	serine-type peptidase activity
GO:0046872	metal ion binding
GO:0070325	lipoprotein particle receptor binding
GO:0070326	very-low-density lipoprotein particle receptor binding

Biological Process

GO:0000904	cell morphogenesis involved in differentiation
GO:0001764	neuron migration
GO:0006508	proteolysis
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0007417	central nervous system development
GO:0007420	brain development
GO:0007616	long-term memory
GO:0008306	associative learning
GO:0010001	glial cell differentiation
GO:0010468	regulation of gene expression
GO:0010976	positive regulation of neuron projection development
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0016358	dendrite development
GO:0016477	cell migration
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0021511	spinal cord patterning
GO:0021517	ventral spinal cord development
GO:0021766	hippocampus development
GO:0021800	cerebral cortex tangential migration
GO:0021819	layer formation in cerebral cortex
GO:0021987	cerebral cortex development
GO:0030900	forebrain development
GO:0032008	positive regulation of TOR signaling
GO:0032793	positive regulation of CREB transcription factor activity
GO:0035418	protein localization to synapse
GO:0038026	reelin-mediated signaling pathway
GO:0045860	positive regulation of protein kinase activity
GO:0048265	response to pain
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050795	regulation of behavior
GO:0050804	regulation of synaptic transmission
GO:0051057	positive regulation of small GTPase mediated signal transduction
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0061003	positive regulation of dendritic spine morphogenesis
GO:0061098	positive regulation of protein tyrosine kinase activity
GO:0090129	positive regulation of synapse maturation
GO:0097107	postsynaptic density assembly
GO:0097114	N-methyl-D-aspartate receptor clustering
GO:0097119	postsynaptic density protein 95 clustering
GO:0097120	receptor localization to synapse
GO:0097477	lateral motor column neuron migration
GO:1900273	positive regulation of long-term synaptic potentiation
GO:1902078	positive regulation of lateral motor column neuron migration
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:2000463	positive regulation of excitatory postsynaptic membrane potential
GO:2000969	positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0030425	dendrite

Protein Structure and Domains

PDB ID

MGI:103022

InterPro

IPR000742 Epidermal growth factor-like domain
IPR002860 BNR repeat
IPR002861 Reeler domain
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011040 Sialidases
IPR013111 EGF-like domain, extracellular

PFAM

PF00008
PF02012
PF02014
PF07974

PRINTS

PIRSF

SMART

SM00181

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q60841