InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Anxa11

Summary

InnateDB Gene

IDBG-138985.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Anxa11

Gene Name

annexin A11

Synonyms

A830099O17Rik; Anx11

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021866

Encoded Proteins

IDBP-138987

annexin A11

IDBP-256166

annexin A11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122359:
This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:25842156-25886804

Strand

Forward strand

Band

Transcripts

ENSMUST00000022416	ENSMUSP00000022416
ENSMUST00000112364	ENSMUSP00000107983
ENSMUST00000124704
ENSMUST00000133547

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0008429	phosphatidylethanolamine binding
GO:0023026	MHC class II protein complex binding
GO:0044548	S100 protein binding
GO:0044822	poly(A) RNA binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006909	phagocytosis
GO:0007109	cytokinesis, completion of separation
GO:0051592	response to calcium ion

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0016020	membrane
GO:0030496	midbody
GO:0042470	melanosome
GO:0042581	specific granule
GO:0042582	azurophil granule
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000122359

View Gene Order

ENSBTAG00000020940

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

NetPath_11

TCR pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.482673

RefSeq

NM_013469 XM_006518451

OMIM

CCDS

CCDS26875

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas