InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ANXA11

Summary

InnateDB Gene

IDBG-80290.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ANXA11

Gene Name

annexin A11

Synonyms

ANX11; CAP50

Species

Homo sapiens

Ensembl Gene

ENSG00000122359

Encoded Proteins

IDBP-80296

annexin A11

IDBP-80298

annexin A11

IDBP-381384

annexin A11

IDBP-381389

annexin A11

IDBP-381391

annexin A11

IDBP-381396

annexin A11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008]
This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:80150889-80205572

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000265447	ENSP00000265447
ENST00000372231	ENSP00000361305
ENST00000438331	ENSP00000398610
ENST00000422982	ENSP00000404412
ENST00000447489	ENSP00000405009
ENST00000437799	ENSP00000414642
ENST00000463340
ENST00000481805
ENST00000463657
ENST00000474545

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005544	calcium-dependent phospholipid binding
GO:0008429	phosphatidylethanolamine binding
GO:0023026	MHC class II protein complex binding
GO:0044548	S100 protein binding
GO:0044822	poly(A) RNA binding
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0006909	phagocytosis
GO:0007109	cytokinesis, completion of separation
GO:0051592	response to calcium ion

Cellular Component

GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0016020	membrane
GO:0030496	midbody
GO:0042470	melanosome
GO:0042581	specific granule
GO:0042582	azurophil granule
GO:0045335	phagocytic vesicle
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021866

View Gene Order

ENSBTAG00000020940

Not yet available

Pathways

NETPATH

NetPath_11

TCR pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.530291 Hs.594332 Hs.605015

RefSeq

NM_001157 NM_001278407 NM_001278408 NM_001278409 NM_145868 NM_145869

HUGO

OMIM

CCDS

CCDS60576 CCDS7364

HPRD

03983

IMGT

EMBL

GenPept

RNA Seq Atlas