InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tas2r138

Summary

InnateDB Gene

IDBG-139419.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tas2r138

Gene Name

taste receptor, type 2, member 138

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000058250

Encoded Proteins

IDBP-139421

taste receptor, type 2, member 138

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000257138:
This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:40612315-40613310

Strand

Reverse strand

Band

Transcripts

ENSMUST00000076565

ENSMUSP00000075876

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008527	taste receptor activity
GO:0033038	bitter taste receptor activity

Biological Process

GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007186	G-protein coupled receptor signaling pathway
GO:0050909	sensory perception of taste