Version 5.4
Mus musculus Gene: Mll5
Summary
InnateDB Gene IDBG-139425.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mll5
Gene Name myeloid/lymphoid or mixed-lineage leukemia 5
Synonyms 1810033J14Rik; 9530077A04Rik; D230038D11Rik; Mll5; NKp44L
Species Mus musculus
Ensembl Gene ENSMUSG00000029004
Encoded Proteins
IDBP-139431
myeloid/lymphoid or mixed-lineage leukemia 5
IDBP-250302
myeloid/lymphoid or mixed-lineage leukemia 5
IDBP-787763
lysine (K)-specific methyltransferase 2E
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000005483:
This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a protein with an N-terminal PHD zinc finger and a central SET domain. Overexpression of the protein inhibits cell cycle progression. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:23434441-23504235
Strand Forward strand
Band A3
Transcripts
ENSMUST00000094962 ENSMUSP00000092569
ENSMUST00000115128 ENSMUSP00000110781
ENSMUST00000146375
ENSMUST00000126586 ENSMUSP00000141126
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019899 enzyme binding
GO:0042800 histone methyltransferase activity (H3-K4 specific)
Biological Process
GO:0002446 neutrophil mediated immunity
GO:0006306 DNA methylation
GO:0006351 transcription, DNA-templated
GO:0007050 cell cycle arrest
GO:0030218 erythrocyte differentiation
GO:0030854 positive regulation of granulocyte differentiation
GO:0042119 neutrophil activation
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048384 retinoic acid receptor signaling pathway
GO:0051568 histone H3-K4 methylation
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0016607 nuclear speck
GO:0070688 MLL5-L complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000005483
View Gene Order
ENSBTAG00000009207
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu00310
Lysine degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.205190
RefSeq NM_026984 XM_006535805
OMIM
CCDS CCDS51430
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca