Version 5.4
Mus musculus Gene: Trps1
Summary
InnateDB Gene IDBG-139644.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trps1
Gene Name trichorhinophalangeal syndrome I (human)
Synonyms AI115454; AI447310; D15Ertd586e
Species Mus musculus
Ensembl Gene ENSMUSG00000038679
Encoded Proteins
IDBP-139646
trichorhinophalangeal syndrome I (human)
IDBP-626586
trichorhinophalangeal syndrome I (human)
IDBP-787582
trichorhinophalangeal syndrome I (human)
IDBP-787583
trichorhinophalangeal syndrome I (human)
IDBP-787584
trichorhinophalangeal syndrome I (human)
IDBP-787585
trichorhinophalangeal syndrome I (human)
IDBP-787586
trichorhinophalangeal syndrome I (human)
IDBP-787587
trichorhinophalangeal syndrome I (human)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104447:
This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:50654752-50890463
Strand Reverse strand
Band C
Transcripts
ENSMUST00000077935 ENSMUSP00000077089
ENSMUST00000165201 ENSMUSP00000129779
ENSMUST00000184458 ENSMUSP00000139063
ENSMUST00000183757 ENSMUSP00000139017
ENSMUST00000183997 ENSMUSP00000139115
ENSMUST00000184885 ENSMUSP00000138905
ENSMUST00000183421 ENSMUSP00000138835
ENSMUST00000185183 ENSMUSP00000138967
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002062 chondrocyte differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0031063 regulation of histone deacetylation
GO:0032330 regulation of chondrocyte differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000104447
View Gene Order
ENSBTAG00000017694
Not yet available
Cross-References
SwissProt
TrEMBL H7BU26 Q8K1J0 V9GX39 V9GXE9
UniProt Splice Variant
Entrez Gene 83925
UniGene
RefSeq NM_032000 XM_006521561
OMIM
CCDS CCDS27460
HPRD
IMGT
MGI ID MGI:1927616
MGI Symbol Trps1
EMBL AC112158 AC142245 AC155307 BC037058 CH466545 JQ665268
GenPept AAH37058 AFB77191 EDL29243
RNA Seq Atlas 83925

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca