Version 5.4
Bos taurus Gene: TRPS1
Summary
InnateDB Gene IDBG-644904.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRPS1
Gene Name zinc finger transcription factor Trps1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000017694
Encoded Proteins
IDBP-697569
trichorhinophalangeal syndrome I
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104447:
This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:50844179-51066191
Strand Forward strand
Band
Transcripts
ENSBTAT00000038232 ENSBTAP00000038047
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0002062 chondrocyte differentiation
GO:0006355 regulation of transcription, DNA-templated
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0031063 regulation of histone deacetylation
GO:0032330 regulation of chondrocyte differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000104447
View Gene Order
ENSMUSG00000038679
View Gene Order
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.70133
RefSeq NM_001192913
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca