InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rad21

Summary

InnateDB Gene

IDBG-139998.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rad21

Gene Name

RAD21 homolog (S. pombe)

Synonyms

mKIAA0078; SCC1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022314

Encoded Proteins

IDBP-140000

RAD21 homolog (S. pombe)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 12198550

[Homo sapiens] RAD21 is part of the cohesin complex which is the cellular machinery involved in sister chromatid cohesion and that which requires access to the nucleosomal DNA to perform its function in chromosome segregation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164754:
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:51962605-51991760

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022927

ENSMUSP00000022927

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 218 interaction(s) predicted by orthology.

Experimentally validated
Total	29 [view]
Protein-Protein	28 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	218 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006915	apoptotic process
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division
GO:0071168	protein localization to chromatin

Cellular Component

GO:0000228	nuclear chromosome
GO:0000775	chromosome, centromeric region
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0008278	cohesin complex
GO:0016020	membrane
GO:0034991	nuclear meiotic cohesin complex