InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc30a8

Summary

InnateDB Gene

IDBG-140142.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc30a8

Gene Name

solute carrier family 30 (zinc transporter), member 8

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022315

Encoded Proteins

IDBP-140144

solute carrier family 30 (zinc transporter), member 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164756:
The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:52295553-52335798

Strand

Forward strand

Band

Transcripts

ENSMUST00000037240

ENSMUSP00000035257

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005385	zinc ion transmembrane transporter activity
GO:0008324	cation transmembrane transporter activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006812	cation transport
GO:0006829	zinc ion transport
GO:0006882	cellular zinc ion homeostasis
GO:0009749	response to glucose
GO:0030073	insulin secretion
GO:0032024	positive regulation of insulin secretion
GO:0032119	sequestering of zinc ion
GO:0034341	response to interferon-gamma
GO:0055085	transmembrane transport
GO:0060627	regulation of vesicle-mediated transport
GO:0061088	regulation of sequestering of zinc ion
GO:0070555	response to interleukin-1
GO:0071577	zinc ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030141	secretory granule
GO:0030658	transport vesicle membrane
GO:0031410	cytoplasmic vesicle