InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc30a8

Summary

InnateDB Protein

IDBP-140144.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc30a8

Protein Name

solute carrier family 30 (zinc transporter), member 8

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035257

InnateDB Gene

IDBG-140142 (Slc30a8)

Protein Structure

UniProt Annotation

Function

Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-secreting pancreatic beta- cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Associated with the insulin and glucagon secretory granules. {ECO:0000269PubMed:19095428}.

Disease Associations

Tissue Specificity

Expressed in endocrine pancreatic islet alpha and beta cells. Not detected in the brain. {ECO:0000269PubMed:16984975, ECO:0000269PubMed:18250168, ECO:0000269PubMed:19095428}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005385	zinc ion transmembrane transporter activity
GO:0008324	cation transmembrane transporter activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0006812	cation transport
GO:0006829	zinc ion transport
GO:0006882	cellular zinc ion homeostasis
GO:0009749	response to glucose
GO:0030073	insulin secretion
GO:0032024	positive regulation of insulin secretion
GO:0032119	sequestering of zinc ion
GO:0034341	response to interferon-gamma
GO:0055085	transmembrane transport
GO:0060627	regulation of vesicle-mediated transport
GO:0061088	regulation of sequestering of zinc ion
GO:0070555	response to interleukin-1
GO:0071577	zinc ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030141	secretory granule
GO:0030658	transport vesicle membrane
GO:0031410	cytoplasmic vesicle