Version 5.4
Mus musculus Gene: Khdrbs2
Summary
InnateDB Gene IDBG-140349.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Khdrbs2
Gene Name KH domain containing, RNA binding, signal transduction associated 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000026058
Encoded Proteins
IDBP-140351
KH domain containing, RNA binding, signal transduction associated 2
IDBP-790554
KH domain containing, RNA binding, signal transduction associated 2
IDBP-790555
KH domain containing, RNA binding, signal transduction associated 2
IDBP-790556
KH domain containing, RNA binding, signal transduction associated 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is similar to the src associated in mitosis, 68 kDa protein, which is an RNA-binding protein and a substrate for Src-family tyrosine kinases during mitosis. This protein has a KH RNA-binding motif and proline-rich motifs which may be SH2 and SH3 domain binding sites. A similar rat protein is an RNA-binding protein which is tyrosine phosphorylated by Src during mitosis. These studies also suggest that the rat protein may function as an adaptor protein for Src by binding the SH2 and SH3 domains of various other proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:32172720-32658564
Strand Forward strand
Band B
Transcripts
ENSMUST00000027226 ENSMUSP00000027226
ENSMUST00000189878 ENSMUSP00000141095
ENSMUST00000188257 ENSMUSP00000140157
ENSMUST00000185666 ENSMUSP00000140451
ENSMUST00000186984
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 49 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005070 SH3/SH2 adaptor activity
GO:0005515 protein binding
GO:0008143 poly(A) binding
GO:0008266 poly(U) RNA binding
GO:0017124 SH3 domain binding
GO:0042169 SH2 domain binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009967 positive regulation of signal transduction
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112232
View Gene Order
ENSBTAG00000043990
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 170771
UniGene
RefSeq NM_133235
OMIM
CCDS CCDS14861
HPRD
IMGT
MGI ID MGI:2159649
MGI Symbol Khdrbs2
EMBL
GenPept
RNA Seq Atlas 170771

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca