InnateDB Protein
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IDBP-140351.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Khdrbs2
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Protein Name
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KH domain containing, RNA binding, signal transduction associated 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000027226
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InnateDB Gene
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IDBG-140349 (Khdrbs2)
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Protein Structure
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Function |
RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion (By similarity). Its phosphorylation by FYN inhibits its ability to regulate splice site selection (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer (By similarity). May function as an adapter protein for Src kinases during mitosis. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability. {ECO:0000250, ECO:0000269PubMed:10077576, ECO:0000269PubMed:15471878}.
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Subcellular Localization |
Nucleus {ECO:0000269PubMed:10077576, ECO:0000269PubMed:15471878}.
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Disease Associations |
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Tissue Specificity |
Expressed in heart, skin, brain, colon, spleen, kidney, cervix and testis. {ECO:0000269PubMed:15471878}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 49 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
49 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2159649
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InterPro |
IPR004087
K Homology domain
IPR004088
K Homology domain, type 1
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PFAM |
PF00013
PF13014
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PRINTS |
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PIRSF |
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SMART |
SM00322
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WU01
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PhosphoSite |
PhosphoSite-Q9WU01
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TrEMBL |
Q8C837
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UniProt Splice Variant |
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Entrez Gene |
170771
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UniGene |
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RefSeq |
NP_573498
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MGI ID |
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MGI Symbol |
Khdrbs2
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OMIM |
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CCDS |
CCDS14861
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HPRD |
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IMGT |
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EMBL |
AF098796
AK048524
BC066814
BC132117
BC132119
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GenPept |
AAD20451
AAH66814
AAI32118
AAI32120
BAC33360
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