InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Chrm1

Summary

InnateDB Gene

IDBG-140427.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Chrm1

Gene Name

cholinergic receptor, muscarinic 1, CNS

Synonyms

Chrm-1; M1; M1R

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032773

Encoded Proteins

IDBP-140429

cholinergic receptor, muscarinic 1, CNS

IDBP-619898

cholinergic receptor, muscarinic 1, CNS

IDBP-705297

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168539:
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:8663789-8683587

Strand

Forward strand

Band

Transcripts

ENSMUST00000035444	ENSMUSP00000042632
ENSMUST00000163785	ENSMUSP00000126103
ENSMUST00000177197	ENSMUSP00000135356

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0008144	drug binding
GO:0016907	G-protein coupled acetylcholine receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007213	G-protein coupled acetylcholine receptor signaling pathway
GO:0007274	neuromuscular synaptic transmission
GO:0040012	regulation of locomotion
GO:0043270	positive regulation of ion transport
GO:0046541	saliva secretion
GO:0050890	cognition
GO:0090316	positive regulation of intracellular protein transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0014069	postsynaptic density
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030425	dendrite
GO:0032279	asymmetric synapse
GO:0043679	axon terminus
GO:0045211	postsynaptic membrane